Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699296 | 0.88 | LMNA (0.52) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL9699315 | 0.79 | CNR1 (0.47) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL9699303 | 0.77 | LMNA (0.54) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL10246396 | 0.77 | NPC1 (0.45) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL10246492 | 0.76 | KMT2A (0.45) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL10246205 | 0.76 | NPC1 (0.56) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL5461727 | 0.73 | NPC1 (0.48) | SMN1; SMN2NPC1LMNAALDH1A1MAPT | |
| SCHEMBL8541700 | 0.73 | LMNA (0.64) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL5461858 | 0.70 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 | |
| SCHEMBL8543224 | 0.69 | LMNA (0.65) | SMN1; SMN2NPC1LMNAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |