Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700281 | 0.94 | AGTR1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL9701314 | 0.84 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9700454 | 0.82 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL9702279 | 0.82 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL9700476 | 0.81 | AGTR1 (0.39) | AGTR1AGTR2 | |
| SCHEMBL9701539 | 0.79 | AGTR1 (0.33) | AGTR1AGTR2 | |
| SCHEMBL9702235 | 0.79 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9702654 | 0.78 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9700442 | 0.78 | AGTR1 (0.32) | AGTR1PDE10AAGTR2AKT1 | |
| SCHEMBL9702723 | 0.76 | PPARG (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497516-A1 | Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5124335-A | Hypotensive agents, antiglaucoma agents | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |