Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529277 | 0.89 | AGTR1 (0.37) | AGTR1AGTR2PPARGKDM4EMEN1 | |
| SCHEMBL9530272 | 0.87 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL6005402 | 0.87 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9527802 | 0.86 | AGTR1 (0.43) | AGTR1AGTR2PPARGKDM4EMEN1 | |
| SCHEMBL9527585 | 0.86 | AGTR1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL9527886 | 0.85 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9529791 | 0.85 | AGTR1 (0.36) | AGTR1AGTR2PPARG | |
| SCHEMBL9527893 | 0.85 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9528235 | 0.84 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9527193 | 0.84 | AGTR1 (0.35) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098920-A | Hypotensive agents and treatment of congestive heart failure | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | disclosed |