Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.46 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700687 | 0.80 | HMGB1 (0.52) | PTPN1HMGB1CXCL12LCKKLKB1 | |
| SCHEMBL9700550 | 0.80 | PTPN1 (0.52) | PTPN1HMGB1CXCL12LCKKLKB1 | |
| SCHEMBL27503796 | 0.80 | PPARA (0.56) | PTPN1HMGB1LCKKLKB1CTSB | |
| SCHEMBL30166478 | 0.78 | LCK (0.49) | PTPN1HMGB1CXCL12LCKKLKB1 | |
| SCHEMBL8579663 | 0.78 | SELL (0.41) | ALDH1A1HPGDHSD17B10SELLSELP | |
| SCHEMBL22529565 | 0.77 | MCL1 (0.53) | PTPN1HMGB1CXCL12LCKKLKB1 | |
| SCHEMBL21585536 | 0.77 | GLRA3 (0.49) | PTPN1HMGB1CXCL12ALDH1A1HPGD | |
| SCHEMBL3289845 | 0.76 | KLKB1 (0.71) | PTPN1LCKKLKB1CTSBMMP9 | |
| SCHEMBL27641727 | 0.76 | AKR1C2 (0.52) | PTPN1HMGB1CXCL12LCKKLKB1 | |
| SCHEMBL27662083 | 0.76 | PTPN1 (0.43) | PTPN1HMGB1CXCL12LCKKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | claimed |
| EP-0390102-A2 | Process for the preparation of pyridine-2,3-dicarboxylic acids | CELGENE CORPORATION (US) | 1990-10-03 | — | — | EP | claimed |
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0390102-A2 | Process for the preparation of pyridine-2,3-dicarboxylic acids | CELGENE CORPORATION (US) | 1990-10-03 | — | — | EP | disclosed |