Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478045 | 0.86 | CES1 (0.40) | PDE7A | |
| SCHEMBL10130338 | 0.77 | AHR (0.44) | PDE7A | |
| SCHEMBL7485832 | 0.69 | AHR (0.60) | PDE7A | |
| SCHEMBL7976982 | 0.68 | CES1 (0.35) | — | |
| SCHEMBL10130809 | 0.62 | PARP1 (0.42) | BRD4CREBBP | |
| SCHEMBL20278370 | 0.61 | PDE3B (0.55) | — | |
| SCHEMBL6411297 | 0.60 | AHR (0.53) | PDE7A | |
| SCHEMBL5378136 | 0.59 | CA12 (0.40) | BRD4CREBBP | |
| SCHEMBL8573750 | 0.58 | CES1 (0.69) | PDE7A | |
| SCHEMBL23408301 | 0.57 | AHR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516297-A1 | Pyridazinediones and their use in the treatment of neurological disorders | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | claimed |