Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209469 | 0.88 | — | — | |
| Dimethylamine SCHEMBL9702713 | 0.86 | FFAR3 (0.30) | — | |
| Dimethylamine SCHEMBL9701597 | 0.84 | — | — | |
| Diethylamine SCHEMBL9701283 | 0.83 | EPHX2 (0.33) | TP53 | |
| Oxalic Acid SCHEMBL5875441 | 0.74 | TP53 (0.57) | TP53CYP3A4ALOX15 | |
| Oxalic Acid SCHEMBL5875439 | 0.74 | TP53 (0.57) | TP53CYP3A4ALOX15 | |
| SCHEMBL17704771 | 0.74 | CHRM1 (0.36) | — | |
| Dimethylcarbate SCHEMBL10884971 | 0.72 | TP53 (0.47) | TP53CYP3A4ALOX15 | |
| SCHEMBL43188 | 0.72 | — | — | |
| Methylethylamine SCHEMBL10885397 | 0.71 | NPC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132454-A | Antihypoxic agents | MEIJI SEIKA KAISHA, LTD. (JP) | 1992-07-21 | — | — | US | disclosed |
| US-5066677-A | Antihypoxic agents, treatment of disorders resulting from reduced oxygen supply to brain | MEIJI SEIKA KAISHA, LTD. (JP) | 1991-11-19 | — | — | US | disclosed |
| EP-0387074-A2 | Novel oxamic acid compounds and pharmaceutical composition for use in improvement of damaged cerebral functions of brain | MEIJI SEIKA KAISHA LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |