Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9700399 | 0.87 | EPHX2 (0.35) | EPHX2KDM5AKDM4CCA12CA2 | |
| Diethylamine SCHEMBL9701558 | 0.83 | TP53 (0.36) | TP53 | |
| SCHEMBL42469 | 0.74 | — | — | |
| SCHEMBL23617956 | 0.72 | EPHX2 (0.33) | EPHX2KDM5AKDM4CCA12CA2 | |
| Hydrochloric Acid SCHEMBL10822824 | 0.72 | — | — | |
| Oxalic Acid SCHEMBL5875441 | 0.71 | TP53 (0.57) | TP53 | |
| Oxalic Acid SCHEMBL5875439 | 0.71 | TP53 (0.57) | TP53 | |
| SCHEMBL9702710 | 0.70 | CA12 (0.36) | EPHX2KDM5AKDM4CCA12CA2 | |
| SCHEMBL14098937 | 0.70 | EPHX2 (0.38) | EPHX2TP53CA12CA2CA9 | |
| SCHEMBL9701553 | 0.70 | MCHR1 (0.35) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132454-A | Antihypoxic agents | MEIJI SEIKA KAISHA, LTD. (JP) | 1992-07-21 | — | — | US | disclosed |
| US-5066677-A | Antihypoxic agents, treatment of disorders resulting from reduced oxygen supply to brain | MEIJI SEIKA KAISHA, LTD. (JP) | 1991-11-19 | — | — | US | disclosed |
| EP-0387074-A2 | Novel oxamic acid compounds and pharmaceutical composition for use in improvement of damaged cerebral functions of brain | MEIJI SEIKA KAISHA LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |