Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9505365 | 0.82 | NPC1 (0.51) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9590051 | 0.82 | ALOX5 (0.58) | ALOX5 | |
| SCHEMBL13696704 | 0.82 | NPC1 (0.51) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9584906 | 0.81 | NPC1 (0.53) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9590136 | 0.81 | ALOX5 (0.57) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9585158 | 0.81 | ALOX5 (0.57) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9503959 | 0.81 | NPC1 (0.50) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9503952 | 0.79 | ALOX5 (0.52) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9427636 | 0.78 | ALOX5 (0.58) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL9508076 | 0.77 | ALOX5 (0.55) | NPC1RAB9AMAPTL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084575-A | Drugs for the treatment of rhinitis, asthma and skin disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |