Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.68 |
| ▸ | PARP1 | P09874 | 2/20 | 0.68 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.68 |
| ▸ | HPGDS | O60760 | 1/20 | 0.64 |
| ▸ | PLAU | P00749 | 4/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | PLAT | P00750 | 2/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11810869 | 0.84 | KDM4E (0.75) | KDM4ECA1CA2PLAUALDH1A1 | |
| SCHEMBL2363489 | 0.83 | LCK (0.78) | KDM4EPARP10PARP1PARP4CA1 | |
| SCHEMBL7567274 | 0.83 | LCK (0.61) | KDM4EPARP10PARP1PARP4CA1 | |
| SCHEMBL29793856 | 0.82 | KDM4E (0.72) | KDM4EPLAUCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL34463427 | 0.82 | KDM4E (1.00) | KDM4ECA1CA2PLAUALDH1A1 | |
| SCHEMBL246511 | 0.82 | KDM4E (0.72) | KDM4EPLAUCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL8132 | 0.82 | KDM4E (1.00) | KDM4ECA1CA2PLAUALDH1A1 | |
| SCHEMBL3659867 | 0.82 | CYP11B1 (0.68) | PARP1HPGDSPLAUCYP11B1CYP11B2 | |
| SCHEMBL3922405 | 0.81 | LCK (0.55) | KDM4EPARP10PARP1PARP4CA1 | |
| SCHEMBL201761 | 0.81 | PARP10 (1.00) | PARP10PARP1PARP4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4814454-A | ANTIALLERGENS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |