Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 14/20 | 0.73 |
| ▸ | AGTR2 | P50052 | 13/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9499375 | 0.99 | AGTR1 (0.72) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9703039 | 0.89 | AGTR1 (0.72) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9499265 | 0.89 | AGTR1 (0.71) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9703709 | 0.89 | AGTR1 (0.73) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9495212 | 0.88 | AGTR1 (0.72) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9494340 | 0.86 | AGTR1 (0.74) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9495778 | 0.84 | AGTR1 (0.51) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709757 | 0.83 | AGTR1 (0.52) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9496862 | 0.83 | AGTR1 (0.61) | AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL9272556 | 0.83 | AGTR1 (0.51) | AGTR1AGTR2ALOX15TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | claimed |