Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701105 | 0.91 | AGTR1 (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL9702239 | 0.88 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9700459 | 0.87 | AGTR1 (0.39) | AGTR1AGTR2PPARG | |
| SCHEMBL9701144 | 0.85 | AGTR1 (0.36) | AGTR1AGTR2PPARG | |
| SCHEMBL9700483 | 0.80 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL9702561 | 0.79 | AGTR1 (0.40) | AGTR1AGTR2PPARG | |
| SCHEMBL9701455 | 0.79 | AGTR1 (0.37) | AGTR1AGTR2PPARG | |
| SCHEMBL9701178 | 0.78 | PPARG (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL9701468 | 0.77 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9702246 | 0.76 | AGTR1 (0.41) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497516-A1 | Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5124335-A | Hypotensive agents, antiglaucoma agents | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |