Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317871 | 0.84 | MEN1 (0.57) | CYP2C9MAPK1CYP1A2TSHRHIF1A | |
| SCHEMBL31036064 | 0.84 | MEN1 (0.57) | CYP2C9MAPK1CYP1A2TSHRHIF1A | |
| SCHEMBL4625231 | 0.81 | TAAR1 (0.54) | CYP2C9HSD17B10CYP1A2TSHRHIF1A | |
| SCHEMBL14783099 | 0.80 | ABCB11 (0.55) | CYP2C9CYP1A2TSHRMEN1KMT2A | |
| SCHEMBL4912776 | 0.79 | HDAC1 (0.58) | CYP2C9MAPK1CYP1A2TSHRHIF1A | |
| SCHEMBL7533082 | 0.79 | HSD17B10 (0.43) | PTPN1CYP2C9HSD17B10TSHRHIF1A | |
| SCHEMBL10360541 | 0.79 | HIF1A (0.60) | CYP2C9MAPK1CYP1A2TSHRHIF1A | |
| SCHEMBL3323530 | 0.78 | HDAC1 (0.61) | CYP2C9MAPK1CYP1A2TSHRHIF1A | |
| SCHEMBL4915603 | 0.78 | HDAC1 (0.61) | CYP2C9MAPK1CYP1A2TSHRHIF1A | |
| SCHEMBL9121212 | 0.76 | TAAR1 (0.52) | CYP2C9HSD17B10CYP1A2TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4814454-A | ANTIALLERGENS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |