Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9556037 | 0.99 | TDP1 (0.55) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL4500135 | 0.84 | SLC6A4 (0.52) | EGFRFGFR1FLT1FLT4KDR | |
| Hydrochloric Acid SCHEMBL19834085 | 0.82 | SLC6A4 (0.51) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL22463006 | 0.81 | EGFR (0.51) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL30272614 | 0.81 | EGFR (0.51) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL13034357 | 0.81 | RBP4 (0.58) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL791939 | 0.80 | TDP1 (0.59) | TDP1SLC6A4HTR3AHTR2CSLC6A2 | |
| Hydrochloric Acid SCHEMBL3100548 | 0.80 | RBP4 (0.57) | EGFRFGFR1FLT1FLT4KDR | |
| Hydrochloric Acid SCHEMBL1474990 | 0.79 | TDP1 (0.62) | TDP1SLC6A4HTR3AHTR2CSLC6A2 | |
| SCHEMBL20428527 | 0.79 | CA12 (0.55) | TDP1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480794-A1 | 2-Aminopyrimidine-4-carboxamide derivatives, their preparation and therapeutic use | SYNTHELABO (FR) | 1992-04-15 | — | — | EP | disclosed |