Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853247 | 0.59 | PDE3B (0.38) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL721458 | 0.59 | GRIN2D (0.50) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL4860712 | 0.57 | GRIN2D (0.38) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9379542 | 0.55 | KIF11 (0.50) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL4853253 | 0.55 | PDE3B (0.36) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL2894232 | 0.54 | PDE3B (0.50) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL640124 | 0.54 | GRIA1 (0.70) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL20364045 | 0.54 | PDE3B (0.44) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9703662 | 0.54 | AR (0.52) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL20417283 | 0.53 | GRIN2D (0.46) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4954498-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-09-04 | — | — | US | disclosed |