Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9703130 | 1.00 | NPC1 (0.48) | NPC1RAB9AMAPTATMTP53 | |
| Oxalic Acid SCHEMBL9702271 | 0.82 | NR1H4 (0.50) | NPC1RAB9AMAPTTP53MAOB | |
| Oxalic Acid SCHEMBL9702276 | 0.82 | NR1H4 (0.50) | NPC1RAB9AMAPTTP53MAOB | |
| Oxalic Acid SCHEMBL9702858 | 0.78 | CHRM2 (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL9702846 | 0.78 | CHRM2 (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10420362 | 0.75 | CHRM2 (0.59) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10420357 | 0.75 | CHRM2 (0.59) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL29140055 | 0.72 | ADRA2A (0.41) | MAPTKDM4EHPGDALDH1A1L3MBTL1 | |
| Oxalic Acid SCHEMBL9704110 | 0.72 | CHRM2 (0.46) | CA2CA9CHRM2CHRM4CHRM5 | |
| Oxalic Acid SCHEMBL9704125 | 0.72 | CHRM2 (0.46) | CA2CA9CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259621-B1 | PIPERIDINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-11-25 | — | — | EP | disclosed |
| US-4933353-A | ALZHEIMER*S DISEASE | A/S FERROSAN (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4837241-A | TREATMENT OF ALZEHEIMER*S DISEASE | A/S FERROSAN (DK) | 1989-06-06 | — | — | US | disclosed |
| EP-0259621-A2 | Piperidine compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-03-16 | — | — | EP | disclosed |