Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9773176 | 1.00 | ACE (0.58) | ACESIRT2SIRT1SIRT3CTSL | |
| SCHEMBL9773203 | 1.00 | ACE (0.58) | ACESIRT2SIRT1SIRT3CTSL | |
| SCHEMBL10958280 | 0.90 | SIRT2 (0.53) | ACESIRT2SIRT1SIRT3CTSL | |
| SCHEMBL4397444 | 0.90 | ACE (0.51) | ACELMNAMEN1KMT2A | |
| SCHEMBL4395799 | 0.90 | ACE (0.51) | ACELMNAMEN1KMT2A | |
| SCHEMBL4395801 | 0.90 | ACE (0.51) | ACELMNAMEN1KMT2A | |
| SCHEMBL9773257 | 0.88 | ACE (0.51) | ACESIRT2SIRT1SIRT3 | |
| SCHEMBL9773259 | 0.88 | ACE (0.51) | ACESIRT2SIRT1SIRT3 | |
| SCHEMBL9773262 | 0.88 | ACE (0.51) | ACESIRT2SIRT1SIRT3 | |
| SCHEMBL9773168 | 0.88 | ACE (0.57) | ACELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091427-A | PIPERAZINEDIONES HAVING A PSYCHOTROPIC ACTION | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| US-5043346-A | Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |