Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | USP7 | Q93009 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9724750 | 0.98 | CHRM1 (0.51) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Oxalic Acid SCHEMBL9704125 | 0.92 | CHRM2 (0.46) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Oxalic Acid SCHEMBL9704110 | 0.92 | CHRM2 (0.46) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Oxalic Acid SCHEMBL9404509 | 0.87 | POLB (0.48) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Oxalic Acid SCHEMBL9404299 | 0.87 | POLB (0.45) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL9724619 | 0.76 | CHRM2 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL10518946 | 0.74 | USP7 (0.41) | USP7POLBCASP3SENP7SENP6 | |
| SCHEMBL24434496 | 0.73 | CHRM2 (0.56) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL9724764 | 0.73 | CHRM2 (0.56) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL9724711 | 0.73 | CHRM2 (0.52) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259621-B1 | PIPERIDINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-11-25 | — | — | EP | claimed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | claimed |
| US-4837241-A | TREATMENT OF ALZEHEIMER*S DISEASE | A/S FERROSAN (DK) | 1989-06-06 | — | — | US | claimed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |