Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10420374 | 0.91 | HSD17B10 (0.36) | KDM4EMAPTHPGDALDH1A1GAA | |
| SCHEMBL10419891 | 0.82 | PLK1 (0.35) | MAPTHPGDGAASMN1; SMN2NPC1 | |
| SCHEMBL9704923 | 0.79 | CHRM2 (0.52) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL9703140 | 0.78 | GABRA1 (0.37) | KDM4EHSD17B10SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9703181 | 0.75 | CHRM2 (0.53) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9704946 | 0.74 | CHRM2 (0.54) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10418509 | 0.74 | TSHR (0.35) | KDM4EMAPTHPGDALDH1A1GAA | |
| SCHEMBL10418513 | 0.74 | CHRM2 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9702952 | 0.73 | CHRM2 (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10418871 | 0.72 | CHRM2 (0.47) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259621-B1 | PIPERIDINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-11-25 | — | — | EP | disclosed |
| US-4933353-A | ALZHEIMER*S DISEASE | A/S FERROSAN (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4837241-A | TREATMENT OF ALZEHEIMER*S DISEASE | A/S FERROSAN (DK) | 1989-06-06 | — | — | US | disclosed |
| EP-0259621-A2 | Piperidine compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-03-16 | — | — | EP | disclosed |