Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703304 | 1.00 | PREP (0.60) | PREPGFERCTRB1NPSR1KMT2A | |
| SCHEMBL9702694 | 0.89 | PREP (0.62) | PREPGFERCTRB1NPSR1KMT2A | |
| SCHEMBL9702688 | 0.89 | PREP (0.62) | PREPGFERCTRB1NPSR1KMT2A | |
| SCHEMBL9702301 | 0.89 | PREP (0.59) | PREPGFERNPSR1KMT2AMEN1 | |
| SCHEMBL9702297 | 0.89 | PREP (0.59) | PREPGFERNPSR1KMT2AMEN1 | |
| Z-Pro-Prolinal SCHEMBL7272251 | 0.87 | PREP (0.67) | PREPCTRB1NPSR1KMT2ATSHR | |
| Z-Pro-Prolinal SCHEMBL1219336 | 0.87 | PREP (0.67) | PREPCTRB1NPSR1KMT2ATSHR | |
| Z-Pro-Prolinal SCHEMBL1380758 | 0.87 | PREP (0.67) | PREPCTRB1NPSR1KMT2ATSHR | |
| SCHEMBL8639445 | 0.85 | PREP (0.65) | PREPCTRB1NPSR1KMT2ATSHR | |
| SCHEMBL3560856 | 0.84 | TSHR (0.51) | PREPGFERNPSR1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118811-A | Treatment and prevention of dementia and amnesia | JAPAN TOBACCO INC. (JP) | 1992-06-02 | — | — | US | claimed |
| EP-0419683-A1 | NEW AMINO ACID DERIVATIVES HAVING PROLYLENDOPEPTIDASE INHIBITOR ACTIVITY | Japan Tobacco Inc. (JP) | 1991-04-03 | — | — | EP | claimed |
| US-5118811-A | Treatment and prevention of dementia and amnesia | JAPAN TOBACCO INC. (JP) | 1992-06-02 | — | — | US | disclosed |
| EP-0419683-A1 | NEW AMINO ACID DERIVATIVES HAVING PROLYLENDOPEPTIDASE INHIBITOR ACTIVITY | Japan Tobacco Inc. (JP) | 1991-04-03 | — | — | EP | disclosed |