Sucrose

Sucrose

SCHEMBL9704445

O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.[K]

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Sucrose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 1/20 0.71
CCNB1 P14635 1/20 0.71
CA2 P00918 1/20 0.49
CA9 Q16790 1/20 0.49
LDHA P00338 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
EPHX2 P34913 4/20 0.42
MAPT P10636 1/20 0.39
TYR P14679 1/20 0.38
ADORA1 P30542 1/20 0.38
PTPN1 P18031 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sucrose SCHEMBL9704105 1.00 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL3024351 1.00 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL10405566 0.99 CDK1 (0.73) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL367818 0.99 CDK1 (0.73) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL5972243 0.97 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL6376479 0.97 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL1001769 0.97 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL2065050 0.97 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL9747719 0.97 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA
Sucrose SCHEMBL1272574 0.97 CDK1 (0.71) CDK1CCNB1CA2CA9LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0230023-B1 PHARMACEUTICAL COMPOSITIONS FOR THE ENHANCEMENT OF WOUND HEALING MARION MERRELL DOW INC. (US) 1992-09-02 EP disclosed
US-4912093-A Polysulfated (mono- or oligo-)saccharide MARION LABORATORIES, INC. (US) 1990-03-27 US disclosed
EP-0230023-A2 Pharmaceutical compositions for the enhancement of wound healing MARION MERRELL DOW INC. (US) 1987-07-29 EP disclosed