Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | EYA2 | O00167 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | MVD | P53602 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187737 | 0.80 | MCL1 (0.36) | LMNANQO1 | |
| SCHEMBL10405288 | 0.79 | — | — | |
| SCHEMBL15601939 | 0.77 | TDP1 (0.38) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL9437064 | 0.76 | TDP1 (0.33) | TDP1EYA2APPACEMVD | |
| SCHEMBL13897445 | 0.76 | TSHR (0.40) | KDM4ETSHRNQO1 | |
| SCHEMBL9474699 | 0.76 | NQO1 (0.33) | NQO1 | |
| SCHEMBL24945004 | 0.75 | CYP3A4 (0.33) | NQO1 | |
| SCHEMBL6159388 | 0.75 | ALDH1A1 (0.34) | TDP1EYA2APPACEMVD | |
| SCHEMBL968737 | 0.74 | — | — | |
| SCHEMBL14134635 | 0.73 | NPC1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-0194972-B1 | NOVEL CYCLOSPORINS | SANDOZ AG (CH) | 1992-07-29 | — | — | EP | disclosed |
| EP-0194972-A2 | Novel cyclosporins | SANDOZ AG (CH) | 1986-09-17 | — | — | EP | disclosed |