Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 8/20 | 0.44 |
| ▸ | BRD4 | O60885 | 7/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HTR5A | P47898 | 3/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703779 | 0.84 | BRD4 (0.38) | CREBBPBRD4EP300PGRAR | |
| SCHEMBL10914693 | 0.80 | BRD4 (0.50) | CREBBPBRD4EP300CES1 | |
| SCHEMBL9035052 | 0.75 | NOTUM (0.44) | CREBBPBRD4EP300HTR2CHTR1A | |
| SCHEMBL9582635 | 0.75 | NOTUM (0.44) | CREBBPBRD4EP300HTR2CHTR1A | |
| SCHEMBL10619645 | 0.75 | CREBBP (0.41) | CREBBPBRD4EP300PGRAR | |
| SCHEMBL13960206 | 0.72 | CES1 (0.36) | CREBBPCES1HTR2CHTR2AHTR2B | |
| SCHEMBL9704675 | 0.69 | CES1 (0.39) | CREBBPBRD4EP300CES1PGR | |
| SCHEMBL10914586 | 0.67 | CES1 (0.42) | CREBBPBRD4EP300CES1TSHR | |
| SCHEMBL9819147 | 0.67 | PBRM1 (0.46) | CREBBPBRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6419356 | 0.66 | CREBBP (0.59) | CREBBPBRD4EP300TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203795-B1 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4720495-A | Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection | TOKYO TANABE CO. LIMITED (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0203795-A2 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1986-12-03 | — | — | EP | disclosed |