Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10619645 | 0.85 | CREBBP (0.41) | BRD4CREBBPEP300ARPGR | |
| SCHEMBL9704634 | 0.84 | CREBBP (0.44) | BRD4CREBBPEP300ARPGR | |
| SCHEMBL15311795 | 0.77 | HTR2C (0.39) | BRD4CREBBPEP300PGRCYP2C9 | |
| SCHEMBL10914693 | 0.74 | BRD4 (0.50) | BRD4CREBBPEP300SMARCA2SMARCA4 | |
| SCHEMBL11724231 | 0.69 | ACHE (0.47) | BRD4CREBBPEP300ARPGR | |
| SCHEMBL10401777 | 0.69 | HTR2A (0.41) | ARDAOALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9704586 | 0.69 | CREBBP (0.43) | BRD4CREBBPEP300ARPGR | |
| SCHEMBL11172350 | 0.68 | HTR2C (0.40) | ARPGR | |
| SCHEMBL31170704 | 0.68 | HTR2C (0.40) | ARPGR | |
| SCHEMBL10914586 | 0.68 | CES1 (0.42) | BRD4CREBBPEP300CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946844-A | Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient | TOKYO TANABE CO., LTD. (JP) | 1990-08-07 | — | — | US | claimed |
| EP-0203795-B1 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4946844-A | Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient | TOKYO TANABE CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0323189-A2 | Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient | TOKYO TANABE COMPANY LIMITED (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4720495-A | Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection | TOKYO TANABE CO. LIMITED (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0203795-A2 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1986-12-03 | — | — | EP | disclosed |