SCHEMBL9705436

SCHEMBL9705436

COc1ccc(CN(C(=O)Nc2c(C(C)C)cccc2C(C)C)[C@H]2CC[C@H](c3ccccc3)CC2)cc1OC

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
UBE2M P61081 12/20 0.54
DCUN1D1 Q96GG9 12/20 0.54
LMNA P02545 2/20 0.41
REN P00797 2/20 0.41
MAPT P10636 1/20 0.41
THRB P10828 1/20 0.41
LPAR1 Q92633 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9265974 1.00 UBE2M (0.54) UBE2MDCUN1D1LMNARENMAPT
SCHEMBL9270258 0.91 UBE2M (0.47) UBE2MDCUN1D1LPAR1
SCHEMBL9270256 0.91 UBE2M (0.47) UBE2MDCUN1D1LPAR1
SCHEMBL9273263 0.90 UBE2M (0.46) UBE2MDCUN1D1LPAR1
SCHEMBL9273258 0.90 UBE2M (0.46) UBE2MDCUN1D1LPAR1
SCHEMBL9271691 0.87 UBE2M (0.66) UBE2MDCUN1D1
SCHEMBL9271539 0.87 UBE2M (0.66) UBE2MDCUN1D1
SCHEMBL9271537 0.87 UBE2M (0.66) UBE2MDCUN1D1
SCHEMBL9265896 0.86 UBE2M (0.52) UBE2MDCUN1D1LMNAMAPTLPAR1
SCHEMBL9265902 0.86 UBE2M (0.52) UBE2MDCUN1D1LMNAMAPTLPAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0507291-A1 Cyclohexylurea compounds YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1992-10-07 EP disclosed