Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | OGT | O15294 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269315 | 0.81 | PDE3B (0.49) | PDGFRAMAPK8CDK5CLK4PDE4A | |
| SCHEMBL13973196 | 0.79 | NOTUM (0.49) | PDGFRAMAPK8CDK5CLK4NOTUM | |
| SCHEMBL3490095 | 0.78 | KDM4E (0.50) | PDGFRAMAPK8CDK5CLK4NOTUM | |
| SCHEMBL1522887 | 0.77 | PDGFRA (1.00) | PDGFRAMAPK8CDK5CLK4GAA | |
| SCHEMBL2502604 | 0.73 | TOP2A (0.49) | PDGFRAMAPK8CDK5CLK4CA12 | |
| SCHEMBL3921981 | 0.72 | PDGFRA (0.53) | PDGFRAMAPK8CDK5CLK4NOTUM | |
| SCHEMBL7278194 | 0.69 | NOTUM (0.45) | NOTUMPDE3BPDE3A | |
| SCHEMBL3624277 | 0.69 | PDGFRA (0.59) | PDGFRAMAPK8CDK5CLK4KDM4E | |
| SCHEMBL981801 | 0.67 | ABCG2 (0.40) | PDGFRAMAPK8CDK5CLK4KDM4E | |
| SCHEMBL4348132 | 0.66 | NQO2 (0.48) | KDM4EALDH1A1HPGDHSD17B10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223177-B1 | CARDIOTONIC PHENYL OXAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-19 | — | — | EP | disclosed |