Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 4/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27126276 | 0.85 | KDM5A (0.52) | KDM4CPARP1KDM5AADORA3ADORA2A | |
| SCHEMBL8501957 | 0.81 | PARP1 (0.60) | PARP1 | |
| SCHEMBL9853656 | 0.79 | KDM4C (0.49) | KDM4CGSK3BPARP1 | |
| Alcohol SCHEMBL27310243 | 0.77 | PARP1 (0.56) | PARP1 | |
| SCHEMBL9376294 | 0.77 | KMT2A (0.54) | GSK3BPARP1 | |
| SCHEMBL1586540 | 0.77 | PARP1 (0.55) | PARP1 | |
| SCHEMBL8566027 | 0.76 | KDM4C (0.52) | KDM4CGSK3BPARP1 | |
| SCHEMBL9706231 | 0.75 | PARP1 (0.54) | GSK3BPARP1 | |
| SCHEMBL9052175 | 0.74 | MAPT (0.59) | GSK3BPARP1 | |
| SCHEMBL31338639 | 0.73 | PARP1 (0.49) | KDM4CGSK3BPARP1KDM5AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481614-A1 | Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |