Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alpha-Terpineol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | CES2 | O00748 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | STAT3 | P40763 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TAS2R31 | P59538 | 2/20 | 0.30 |
| ▸ | TAS2R46 | P59540 | 2/20 | 0.30 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Terpineol SCHEMBL28134655 | 0.95 | LMNA (0.89) | LMNACES2CYP3A4ALOX15STAT3 | |
| Alpha-Terpineol SCHEMBL980991 | 0.93 | LMNA (1.00) | LMNACES2CYP3A4ALOX15STAT3 | |
| Alpha-Terpineol SCHEMBL901351 | 0.93 | LMNA (1.00) | LMNACES2CYP3A4ALOX15STAT3 | |
| Alpha-Terpineol SCHEMBL28466 | 0.93 | LMNA (1.00) | LMNACES2CYP3A4ALOX15STAT3 | |
| Alpha-Terpineol SCHEMBL891812 | 0.93 | LMNA (1.00) | LMNACES2CYP3A4ALOX15STAT3 | |
| Alpha-Terpineol SCHEMBL10925321 | 0.93 | LMNA (1.00) | LMNACES2CYP3A4ALOX15STAT3 | |
| Alpha-Terpineol SCHEMBL9562893 | 0.91 | LMNA (0.96) | LMNACES2CYP3A4ALOX15STAT3 | |
| Nephthenol SCHEMBL14828377 | 0.86 | LMNA (0.86) | LMNACES2CYP3A4ALOX15STAT3 | |
| Nephthenol SCHEMBL29713433 | 0.86 | LMNA (0.86) | LMNACES2CYP3A4ALOX15STAT3 | |
| SCHEMBL29477354 | 0.86 | LMNA (0.86) | LMNACES2CYP3A4ALOX15STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034581-A1 | ANTIMICROBIAL COMPOSITION COMPRISING THYMOL AND A TERPINYL DERIVATIVE | UNILEVER N.V. (NL) | 2013-03-14 | — | — | WO | disclosed |
| US-5139562-A | Exposure to cineole, fenchone, menthol | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1992-08-18 | — | — | US | disclosed |
| WO-1992010934-A1 | INHIBITION OF POTATO SPROUTING USING VOLATILE MONOTERPENES | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) | 1992-07-09 | — | — | WO | disclosed |