Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9373478 | 0.95 | HRH3 (0.59) | HRH3MEN1KMT2ACHRNB2CHRNB4 | |
| Oxalic Acid SCHEMBL9371181 | 0.92 | KDM4E (0.58) | HRH3MEN1KMT2AKDM4ECHRNB2 | |
| Oxalic Acid SCHEMBL9531846 | 0.90 | HRH3 (0.64) | HRH3MEN1KMT2ACHRNB2CHRNB4 | |
| Oxalic Acid SCHEMBL9368583 | 0.89 | HRH3 (0.53) | HRH3MEN1KMT2ACHRNB2CHRNB4 | |
| SCHEMBL9369534 | 0.88 | HRH3 (0.54) | HRH3AGER | |
| SCHEMBL9368505 | 0.86 | KCNH2 (0.55) | HRH3MEN1KMT2AKDM4E | |
| Oxalic Acid SCHEMBL9368390 | 0.85 | KMT2A (0.56) | HRH3MEN1KMT2AKDM4E | |
| Oxalic Acid SCHEMBL9368451 | 0.84 | KDM4E (0.55) | HRH3MEN1KMT2AKDM4E | |
| SCHEMBL9371049 | 0.82 | HRH3 (0.48) | HRH3AGER | |
| Oxalic Acid SCHEMBL9369473 | 0.82 | KDM4E (0.61) | HRH3MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022527-A2 | 3-SUBSTITUTED PYRROLIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1992-12-23 | — | — | WO | disclosed |