Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370762 | 0.94 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2HRH3HSP90AA1 | |
| SCHEMBL9696871 | 0.89 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| Oxalic Acid SCHEMBL9373478 | 0.88 | HRH3 (0.59) | MEN1KMT2AHRH3 | |
| Hydrochloric Acid SCHEMBL27357671 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| Oxalic Acid SCHEMBL9697739 | 0.85 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| Oxalic Acid SCHEMBL9368390 | 0.84 | KMT2A (0.56) | KDM4EALDH1A1MEN1KMT2AHRH3 | |
| Oxalic Acid SCHEMBL9706775 | 0.84 | HRH3 (0.54) | KDM4EMEN1KMT2AHRH3 | |
| Oxalic Acid SCHEMBL9531846 | 0.83 | HRH3 (0.64) | MEN1KMT2AHRH3 | |
| Oxalic Acid SCHEMBL9368583 | 0.83 | HRH3 (0.53) | MEN1KMT2AHRH3 | |
| Oxalic Acid SCHEMBL7328948 | 0.83 | DRD4 (0.54) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589971-A1 | COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-06 | — | — | EP | disclosed |
| WO-1992022527-A2 | 3-SUBSTITUTED PYRROLIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1992-12-23 | — | — | WO | disclosed |