⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655586 | 0.79 | DYRK1A (0.31) | — | |
| SCHEMBL8384 | 0.78 | TSHR (0.35) | — | |
| SCHEMBL29503624 | 0.72 | — | — | |
| SCHEMBL365279 | 0.72 | — | — | |
| SCHEMBL18245070 | 0.72 | — | — | |
| SCHEMBL8425182 | 0.72 | — | — | |
| SCHEMBL6281274 | 0.71 | MEN1 (0.40) | — | |
| Lithium SCHEMBL30123866 | 0.70 | TSHR (0.48) | — | |
| SCHEMBL30102568 | 0.70 | TSHR (0.48) | — | |
| Potassium SCHEMBL30102564 | 0.70 | TSHR (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 573 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240033318-A1 | PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION | OHIO STATE INNOVATION FOUNDATION | 2024-02-01 | — | — | US | claimed |
| CN-117186006-A | Nitidine tetracyclic analogue-sulfonamide hybrid, preparation and application | 广西中医药大学 | 2023-12-08 | — | — | CN | claimed |
| US-11576946-B2 | Peptidyl inhibitors of calcineurin-NFAT interaction | OHIO STATE INNOVATION FOUNDATION (US) | 2023-02-14 | — | — | US | claimed |
| CN-114933620-A | Azithromycin derivatives having epithelial barrier enhancing properties | 艾比恩多制药有限责任公司 | 2022-08-23 | — | — | CN | claimed |
| CN-114716587-A | Olefin polymerization solid catalyst component containing phenylacetate compounds, and preparation method and application thereof | 中国科学院化学研究所 | 2022-07-08 | — | — | CN | claimed |
| CN-108290919-B | Azithromycin derivatives having epithelial barrier enhancing properties | 艾比恩多制药有限责任公司 | 2022-06-17 | — | — | CN | claimed |
| US-20220106349-A1 | Compounds | EPIENDO PHARMACEUTICALS EHF (IS) | 2022-04-07 | — | — | US | claimed |
| US-11236120-B2 | Azithromycin derivatives with epithelial barrier enhancement properties | EPIENDO PHARMACEUTICALS EHF (IS) | 2022-02-01 | — | — | US | claimed |
| US-20210169966-A1 | PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | claimed |
| EP-3749365-A2 | PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION | Ohio State Innovation Foundation (US) | 2020-12-16 | — | — | EP | claimed |
| WO-2000012074-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2000-03-09 | — | — | WO | claimed |
| WO-1999052857-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-21 | — | — | WO | claimed |
| WO-1999031068-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-24 | — | — | WO | claimed |
| WO-1999025709-A1 | ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-05-27 | — | — | WO | claimed |
| WO-1999021836-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-06 | — | — | WO | claimed |
| EP-0230347-B1 | MACROLIDE COMPOUNDS, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-15 | — | — | EP | claimed |
| US-4912090-A | Antiparasitic milbemycin and avermectin derivatives | SANKYO COMPANY LIMITED (JP) | 1990-03-27 | — | — | US | claimed |
| US-4912231-A | Reacting a proline derivative with an aromatic nucleophile in presence of a Lewis acid catalyst | E. R. SQUIBB & SONS, INC. (US) | 1990-03-27 | — | — | US | claimed |
| US-4727079-A | Brain-specific dopaminergic activity involving dihydropyridine carboxamides, dihydroquinoline and isoquinoline carboxamides | UNIVERSITY OF FLORIDA (US) | 1988-02-23 | — | — | US | claimed |
| EP-0230347-A1 | Macrolide compounds, their preparation and use | Sankyo Company Limited (JP) | 1987-07-29 | — | — | EP | claimed |