Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | ELOC | Q15369 | 1/20 | 0.40 |
| ▸ | ELOB | Q15370 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chromanone SCHEMBL28794 | 0.76 | MAOB (0.56) | GRM5MAOBMAOAHPGDALDH1A1 | |
| SCHEMBL7417 | 0.76 | VHL (0.56) | VHLELOCELOBMAOBMAOA | |
| SCHEMBL29414923 | 0.76 | VHL (0.56) | VHLELOCELOBMAOBMAOA | |
| Chromanone SCHEMBL28205525 | 0.76 | MAOB (0.56) | GRM5MAOBMAOAHPGDALDH1A1 | |
| Chromanone SCHEMBL29384996 | 0.76 | MAOB (0.56) | GRM5MAOBMAOAHPGDALDH1A1 | |
| Chromanone SCHEMBL29349977 | 0.74 | MAOB (0.55) | GRM5MAOBMAOAHPGDALDH1A1 | |
| Chromanone SCHEMBL30017864 | 0.74 | MAOB (0.55) | GRM5MAOBMAOAHPGDALDH1A1 | |
| Chromanone SCHEMBL28463260 | 0.74 | MAOB (0.55) | GRM5MAOBMAOAHPGDALDH1A1 | |
| Chromanone SCHEMBL27846233 | 0.74 | MAOB (0.55) | GRM5MAOBMAOAHPGDALDH1A1 | |
| Chromanone SCHEMBL28719460 | 0.74 | MAOB (0.55) | GRM5MAOBMAOAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015579-A1 | MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-17 | — | — | WO | disclosed |