Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8988338 | 0.99 | CHRNA7 (0.49) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3206387 | 0.87 | CHRNA7 (0.58) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3218557 | 0.87 | CHRNA7 (0.58) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3222951 | 0.87 | CHRNA7 (0.58) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4197310 | 0.85 | CHRNA7 (0.53) | CHRNA7CHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL8988308 | 0.84 | MAOB (0.46) | CYP2D6BCHEACHE | |
| Hydrochloric Acid SCHEMBL8988206 | 0.83 | CHRNA7 (0.52) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL8988244 | 0.80 | CHRNA7 (0.49) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3210424 | 0.79 | GLA (0.54) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3216566 | 0.79 | CYP1A2 (0.54) | CHRNA7CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015579-A1 | MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-17 | — | — | WO | claimed |