Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | GLA | P06280 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 1/20 | 0.59 |
| ▸ | CCND1 | P24385 | 1/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.59 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14598932 | 0.89 | GAA (0.93) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL276017 | 0.89 | ALDH1A1 (0.65) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL5444428 | 0.89 | ALDH1A1 (1.00) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL6756610 | 0.88 | AHR (0.64) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL29562978 | 0.88 | AHR (0.64) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL870205 | 0.86 | KDM4E (0.65) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL92077 | 0.82 | GAA (0.82) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL13412901 | 0.82 | GAA (0.82) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL22367061 | 0.82 | GAA (0.82) | GAAALDH1A1KDM4EGLAHTT | |
| SCHEMBL29349876 | 0.82 | GAA (0.82) | GAAALDH1A1KDM4EGLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535243-B1 | SUBSTITUTED 9H-XANTHEN-9-ONE, 9H-THIOXANTHEN-9-ONE AND ACRIDIN-9(10H)-ONE DERIVATIVES AND RELATED COMPOUNDS CSF-1R INHIBITORS FOR THE TREATMENT OF CANCER | AUCKLAND UNISERVICES LTD (NZ) | 2021-12-15 | — | — | EP | disclosed |
| US-11028064-B2 | Tricyclic heterocyclic derivatives and uses thereof | AUCKLAND UNISERVICES LIMITED (NZ) | 2021-06-08 | — | — | US | disclosed |
| US-20190276423-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES AND USES THEREOF | AUCKLAND UNISERVICES LIMITED (NZ) | 2019-09-12 | — | — | US | disclosed |
| US-9960366-B2 | Organic light emitting element | CANON KABUSHIKI KAISHA (JP) | 2018-05-01 | — | — | US | disclosed |
| US-20160211467-A1 | ORGANIC LIGHT EMITTING ELEMENT | CANON KABUSHIKI KAISHA (JP) | 2016-07-21 | — | — | US | disclosed |
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11028064-B2 | Tricyclic heterocyclic derivatives and uses thereof | CSF3R, CSF1R, FLT3 | GAA 1415/4885ALDH1A1 2524/4885KDM4E 2855/4885 |
| US-20190276423-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES AND USES THEREOF | CSF3R, CSF1R, FLT3 | GAA 1415/4885ALDH1A1 2524/4885KDM4E 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.