Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3593739 | 0.78 | NPC1 (0.50) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL27140279 | 0.72 | CA9 (0.42) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL27148030 | 0.71 | NPC1 (0.41) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL30062471 | 0.71 | SRD5A1 (0.41) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL852124 | 0.71 | PARP1 (0.47) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL30893045 | 0.71 | NPC1 (0.41) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL27139794 | 0.71 | SRD5A1 (0.41) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL21468468 | 0.70 | MAPT (0.39) | CA9NPC1CRBNALDH1A1MAPT | |
| SCHEMBL9379056 | 0.69 | CYP19A1 (0.39) | CYP19A1ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL18513655 | 0.68 | CA9 (0.42) | CA9NPC1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0473963-A1 | Pyrrolobenzimidazoles, imidazobenzoxazinones, and imidazoquinolones, processes for their preparation and their use as well as compositions containing these compounds | Beiersdorf-Lilly GmbH (DE) | 1992-03-11 | — | — | EP | disclosed |