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SCHEMBL9709541

SCHEMBL9709541

O=C(O)CC[C@H](CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCOc1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ TBXAS1 P24557 20/20 1.00
▸ TBXA2R P21731 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9709493 1.00 TBXAS1 (1.00) TBXAS1TBXA2R
SCHEMBL9709498 1.00 TBXAS1 (1.00) TBXAS1TBXA2R
SCHEMBL9709717 0.91 TBXAS1 (0.84) TBXAS1TBXA2R
SCHEMBL9732694 0.89 TBXAS1 (0.80) TBXAS1TBXA2R
SCHEMBL9709681 0.87 TBXAS1 (0.77) TBXAS1TBXA2R
SCHEMBL9709557 0.85 TBXAS1 (0.74) TBXAS1TBXA2R
SCHEMBL9710116 0.84 TBXAS1 (1.00) TBXAS1TBXA2R
SCHEMBL9709519 0.84 TBXAS1 (1.00) TBXAS1TBXA2R
SCHEMBL9732834 0.80 TBXAS1 (0.68) TBXAS1TBXA2R
SCHEMBL9732149 0.80 TBXAS1 (0.85) TBXAS1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0493324-A1 Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof CIBA-GEIGY AG (CH) 1992-07-01 — — EP claimed
US-5153214-A Treating cardiovascular disorders CIBA-GEIGY CORPORATION (US) 1992-10-06 — — US disclosed
EP-0493324-A1 Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof CIBA-GEIGY AG (CH) 1992-07-01 — — EP disclosed