Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737507 | 0.95 | AGTR1 (0.47) | AGTR1 | |
| SCHEMBL9709530 | 0.90 | AGTR1 (0.43) | AGTR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9709623 | 0.88 | AGTR1 (0.42) | AGTR1 | |
| SCHEMBL9738112 | 0.86 | AGTR1 (0.38) | AGTR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9709744 | 0.85 | AGTR1 (0.47) | AGTR1 | |
| SCHEMBL9709599 | 0.85 | AGTR1 (0.45) | AGTR1 | |
| SCHEMBL9709566 | 0.84 | AGTR1 (0.40) | AGTR1 | |
| SCHEMBL9709777 | 0.83 | AGTR1 (0.43) | AGTR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9710000 | 0.83 | AGTR1 (0.45) | AGTR1 | |
| SCHEMBL9709510 | 0.83 | AGTR1 (0.43) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |