Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | CCR1 | P32246 | 3/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31373510 | 0.81 | CCR1 (0.47) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL829514 | 0.81 | CCR1 (0.47) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL8284604 | 0.81 | PRMT5 (0.68) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL6637754 | 0.78 | PRMT5 (0.59) | PRMT5CCR1CCR8LMNAALDH1A1 | |
| SCHEMBL14649499 | 0.78 | KDM4E (0.47) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL20468597 | 0.78 | PRMT5 (0.50) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL6636369 | 0.78 | PRMT5 (0.50) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL9710251 | 0.77 | PRMT5 (0.46) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL28133510 | 0.77 | PRMT5 (0.42) | PRMT5MAPTL3MBTL1CCR1CCR8 | |
| SCHEMBL14666994 | 0.75 | PRMT5 (0.47) | PRMT5MAPTL3MBTL1CCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |