Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.59 |
| ▸ | NCF1 | P14598 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284604 | 0.81 | PRMT5 (0.68) | PRMT5NCF1LMNAALDH1A1TOP1 | |
| SCHEMBL23676516 | 0.81 | PRMT5 (0.68) | PRMT5LMNAALDH1A1CASP1HSD17B10 | |
| SCHEMBL6636369 | 0.78 | PRMT5 (0.50) | PRMT5TOP1CCR1CCR8CASP6 | |
| SCHEMBL28332633 | 0.78 | PRMT5 (0.50) | PRMT5LMNAALDH1A1CASP1HSD17B10 | |
| SCHEMBL9709737 | 0.78 | PRMT5 (0.50) | PRMT5LMNANR4A2ALDH1A1TOP1 | |
| SCHEMBL20468597 | 0.78 | PRMT5 (0.50) | PRMT5NCF1LMNAALDH1A1HSD17B10 | |
| SCHEMBL9709781 | 0.77 | PRMT5 (0.54) | PRMT5LMNATOP1HRH4CASP6 | |
| SCHEMBL14666994 | 0.75 | PRMT5 (0.47) | PRMT5NCF1LMNAALDH1A1TOP1 | |
| SCHEMBL10266505 | 0.75 | PRMT5 (0.47) | PRMT5NCF1ALDH1A1TOP1CCR1 | |
| Quinoline SCHEMBL28231960 | 0.75 | NCF1 (0.75) | NCF1NR4A2ALDH1A1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144409-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6596730-B1 | Phenyl urea and phenyl thiourea derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-22 | — | — | US | disclosed |
| EP-1144409-A2 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000047576-A1 | CINNAMIDE DERIVATIVES AS OREXIN-1 RECEPTORS ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |
| WO-2000047580-A2 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |