Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | DRD1 | P21728 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709697 | 0.87 | CHRM2 (0.64) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9709964 | 0.84 | SSTR4 (0.50) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL7289564 | 0.84 | CYP2D6 (0.68) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL30280471 | 0.81 | CHRM2 (0.78) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL10673689 | 0.80 | GBA1 (0.53) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL29763485 | 0.80 | KDM4E (0.79) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL28590382 | 0.76 | CHRM2 (0.72) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL30480295 | 0.76 | HTR2A (0.51) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9574825 | 0.76 | CHRM2 (0.58) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9574671 | 0.74 | CHRM2 (0.55) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | claimed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | disclosed |