Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.64 |
| ▸ | DRD1 | P21728 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HRH1 | P35367 | 2/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28590382 | 0.89 | CHRM2 (0.72) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9709954 | 0.87 | CHRM2 (0.50) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL9709964 | 0.87 | SSTR4 (0.50) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL7289564 | 0.87 | CYP2D6 (0.68) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL7095181 | 0.79 | CHRM2 (0.69) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL11700168 | 0.79 | CHRM2 (0.69) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL17970 | 0.78 | CHRM2 (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL29600775 | 0.78 | CHRM2 (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL5609247 | 0.77 | ALDH1A1 (0.57) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL98916 | 0.77 | KDM4E (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | claimed |