Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924829 | 0.81 | HTT (0.75) | KMT2AMEN1HTTRAB9ANPC1 | |
| SCHEMBL29363113 | 0.79 | TMEM97 (0.49) | KMT2AMEN1HTTMETAP1RAB9A | |
| SCHEMBL22556188 | 0.78 | TDP1 (0.61) | KMT2AMEN1METAP1RAB9ANPC1 | |
| SCHEMBL30668778 | 0.76 | METAP1 (0.56) | METAP1RAB9ABRD9NAMPTLMNA | |
| SCHEMBL3243855 | 0.76 | METAP1 (0.56) | METAP1RAB9ABRD9NAMPTLMNA | |
| SCHEMBL5809567 | 0.75 | MAPT (0.48) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL29532149 | 0.75 | METAP1 (0.46) | KMT2AMEN1HTTMETAP1RAB9A | |
| SCHEMBL116767 | 0.74 | MEN1 (0.65) | KMT2AMEN1HTTMETAP1KDM4E | |
| SCHEMBL9709748 | 0.73 | KMT2A (0.56) | KMT2AMEN1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL10266505 | 0.73 | PRMT5 (0.47) | KMT2AMEN1HTTNPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |