Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CD38 | P28907 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709726 | 0.86 | CD38 (0.50) | KMT2AMEN1KDM4ETP53RAD52 | |
| SCHEMBL9709713 | 0.85 | LMNA (0.52) | KMT2AMEN1KDM4ETP53RAD52 | |
| SCHEMBL3924829 | 0.82 | HTT (0.75) | KMT2AMEN1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL7748081 | 0.75 | MAPT (0.57) | KMT2AMEN1TP53POLBSMN1; SMN2 | |
| SCHEMBL30471577 | 0.75 | MAPT (0.57) | KMT2AMEN1TP53POLBSMN1; SMN2 | |
| SCHEMBL10061806 | 0.74 | KMT2A (0.77) | KMT2AMEN1KDM4ETP53RAD52 | |
| SCHEMBL30116113 | 0.74 | AAK1 (0.43) | LCKSMN1; SMN2 | |
| SCHEMBL20671010 | 0.74 | AAK1 (0.43) | LCKSMN1; SMN2 | |
| SCHEMBL12931843 | 0.74 | SMN1; SMN2 (0.45) | KMT2AMEN1HTTPOLBLCK | |
| SCHEMBL9709993 | 0.73 | KMT2A (0.49) | KMT2AMEN1KDM4ETP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |