Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH5 | P11766 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 5/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272043 | 0.78 | PDE3B (0.43) | PDE3BPDE3AKMT2ACYP1A2CYP2C19 | |
| SCHEMBL10756489 | 0.73 | PDE3B (0.55) | ADH5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10771601 | 0.70 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9705393 | 0.70 | NOTUM (0.45) | MEN1KMT2ACYP3A4 | |
| SCHEMBL2533488 | 0.69 | TSHR (0.84) | ADH5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8392834 | 0.69 | MEN1 (0.61) | ADH5PDE3BPDE3APDE2ATSHR | |
| SCHEMBL7342584 | 0.68 | PDE3B (0.49) | ADH5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7266072 | 0.68 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL255498 | 0.68 | MAOB (0.62) | TSHRMEN1ALOX15KMT2ACYP1A2 | |
| SCHEMBL16568283 | 0.68 | PDE3B (0.50) | ADH5PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223177-B1 | CARDIOTONIC PHENYL OXAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-19 | — | — | EP | disclosed |
| US-4728661-A | Cardiotonic phenyl oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |