SCHEMBL9711714

SCHEMBL9711714

O=CCOc1ccc(-n2ccnc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 10/20 0.61
CYP2C9 P11712 9/20 0.61
CYP3A4 P08684 9/20 0.61
CYP1A2 P05177 6/20 0.61
CYP2C19 P33261 5/20 0.61
CYP19A1 P11511 1/20 0.61
CA1 P00915 2/20 0.57
CA2 P00918 2/20 0.57
CA9 Q16790 2/20 0.57
PORCN Q9H237 1/20 0.49
LMNA P02545 1/20 0.49
MAPT P10636 1/20 0.49
ENPP2 Q13822 1/20 0.49
MKNK1 Q9BUB5 1/20 0.49
MKNK2 Q9HBH9 1/20 0.49
NOTUM Q6P988 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8519460 0.84 CYP2D6 (0.61) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL8485506 0.81 CYP2D6 (0.57) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL8794811 0.81 CYP2D6 (0.57) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL5630862 0.81 CYP2D6 (0.61) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL1884647 0.79 CYP2D6 (0.77) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL5256897 0.77 TBXAS1 (0.55) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL6573617 0.76 CYP2D6 (0.72) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL5202195 0.76 CYP2D6 (0.72) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL14129854 0.76 CYP2D6 (1.00) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19
SCHEMBL9471631 0.76 CYP2D6 (0.77) CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0303227-B1 ETHERS AND THIOETHERS HAVING THERAPEUTICAL ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-02-05 EP disclosed