SCHEMBL9712880

SCHEMBL9712880

CCCOc1ccc(C#Cc2ccc(OC(F)(F)C(F)F)cc2)nc1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ACACB O00763 15/20 0.53
MCHR1 Q99705 5/20 0.43
CHRM1 P11229 1/20 0.39
HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10524909 0.95 ACACB (0.50) ACACBMCHR1CHRM1HTR2A
SCHEMBL9712834 0.95 ACACB (0.48) ACACBMCHR1CHRM1HTR2A
SCHEMBL9713534 0.93 ACACB (0.47) ACACBMCHR1CHRM1HTR2A
SCHEMBL9713638 0.92 ACACB (0.46) ACACBMCHR1CHRM1HTR2A
SCHEMBL9713338 0.92 ACACB (0.46) ACACBMCHR1CHRM1HTR2A
SCHEMBL9712812 0.92 ACACB (0.46) ACACBMCHR1CHRM1HTR2A
SCHEMBL9713556 0.90 ACACB (0.52) ACACBMCHR1
SCHEMBL9712769 0.89 ACACB (0.56) ACACBMCHR1CHRM1HTR2A
SCHEMBL9712931 0.85 ACACB (0.49) ACACBMCHR1CHRM1HTR2A
SCHEMBL9713435 0.84 ACACB (0.49) ACACBMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5164114-A LIQUID CRYSTAL MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1992-11-17 US disclosed
EP-0306521-B1 ETHINE DERIVATIVES AS COMPOUNDS OF LIQUID CRYSTAL PHASES MERCK PATENT GmbH (DE) 1991-10-16 EP disclosed