Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713542 | 0.94 | NR1H4 (0.67) | NR1H4THRBSMPD1SMN1; SMN2MAPT | |
| SCHEMBL9713298 | 0.86 | SMPD1 (0.60) | NR1H4THRBSMPD1SMN1; SMN2KMT2A | |
| SCHEMBL9713595 | 0.85 | NR1H4 (0.78) | NR1H4THRBSMPD1SMN1; SMN2MAPT | |
| SCHEMBL9857033 | 0.80 | NR1H4 (0.63) | NR1H4THRBSMPD1SMN1; SMN2MAPT | |
| SCHEMBL11325837 | 0.79 | SMPD1 (0.82) | NR1H4THRBSMPD1KMT2ALMNA | |
| SCHEMBL9131621 | 0.79 | PLK1 (0.56) | NR1H4THRBSMPD1KMT2AMEN1 | |
| SCHEMBL14544616 | 0.78 | THRB (0.65) | NR1H4THRBSMPD1SMN1; SMN2MAPT | |
| SCHEMBL31194774 | 0.78 | SMPD1 (0.80) | NR1H4THRBSMPD1KMT2AMAPK1 | |
| SCHEMBL28224821 | 0.78 | SMPD1 (1.00) | NR1H4THRBSMPD1KMT2A | |
| SCHEMBL28225521 | 0.78 | SMPD1 (1.00) | NR1H4THRBSMPD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140046-A | Slow reacting substance of anaphylaxis antagonists | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |