Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714090 | 0.83 | IDO1 (0.44) | KDM4ENSD2MAPTMAPK1RHEB | |
| SCHEMBL9713604 | 0.81 | MAPT (0.48) | KDM4ENSD2MAPTMAPK1RHEB | |
| SCHEMBL9713681 | 0.78 | AURKA (0.43) | KDM4ENSD2MAPTMAPK1AURKA | |
| SCHEMBL9641655 | 0.77 | KDM4E (0.50) | KDM4ENSD2MAPTMAPK1RHEB | |
| SCHEMBL9713612 | 0.76 | KDM4E (0.42) | KDM4ENSD2MAPTMAPK1AURKA | |
| SCHEMBL30003334 | 0.70 | AURKA (0.53) | KDM4ENSD2MAPTMAPK1AURKA | |
| SCHEMBL9627478 | 0.70 | AURKA (0.53) | KDM4ENSD2MAPTMAPK1AURKA | |
| SCHEMBL9713415 | 0.68 | BCL2 (0.39) | KDM4ENSD2MAPTMAPK1AURKA | |
| SCHEMBL23271871 | 0.67 | AURKA (0.50) | KDM4ENSD2MAPTMAPK1AURKA | |
| SCHEMBL30004050 | 0.67 | AURKA (0.74) | KDM4EMAPTMAPK1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |