Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | P4HB | P07237 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27593809 | 0.81 | AURKA (0.50) | KDM4EMAPTMAPK1AURKAAURKB | |
| SCHEMBL9713755 | 0.80 | IDO1 (0.51) | KDM4EMAPTMAPK1NSD2PDE7A | |
| SCHEMBL9713681 | 0.79 | AURKA (0.43) | KDM4EMAPTMAPK1NSD2AURKA | |
| SCHEMBL9713463 | 0.76 | KDM4E (0.48) | KDM4EMAPTMAPK1NSD2AURKA | |
| SCHEMBL9713604 | 0.76 | MAPT (0.48) | KDM4EMAPTMAPK1NSD2AURKA | |
| SCHEMBL9643244 | 0.72 | MAPT (0.49) | KDM4EMAPTMAPK1NSD2PDE7A | |
| SCHEMBL30003334 | 0.71 | AURKA (0.53) | KDM4EMAPTMAPK1NSD2AURKA | |
| SCHEMBL9627478 | 0.71 | AURKA (0.53) | KDM4EMAPTMAPK1NSD2AURKA | |
| SCHEMBL9628563 | 0.70 | BACE1 (0.49) | KDM4EMAPTMAPK1AURKAAURKB | |
| SCHEMBL23271871 | 0.68 | AURKA (0.50) | KDM4EMAPTMAPK1NSD2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |