Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643170 | 0.79 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9642624 | 0.79 | PREP (0.36) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9642556 | 0.78 | HPGD (0.37) | KDM4EALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL9641858 | 0.74 | BACE1 (0.48) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10502752 | 0.73 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9643184 | 0.72 | MRGPRX4 (0.42) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9628361 | 0.69 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL28380353 | 0.67 | POLB (0.38) | KDM4EALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL9641997 | 0.67 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL11063523 | 0.66 | KDM4E (0.36) | PDE4DKDM4EALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |