Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | MAP2 | P11137 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643170 | 0.81 | PDE4A (0.57) | ABCB11MAPTBACE1PDE4APDE4B | |
| SCHEMBL9641858 | 0.80 | BACE1 (0.48) | ABCB11MAPTPOLBBACE1PDE4A | |
| SCHEMBL9713656 | 0.74 | ABCB11 (0.48) | ABCB11MAP2MAPTPOLBBACE1 | |
| SCHEMBL10503628 | 0.74 | ABCB11 (0.64) | ABCB11MAP2MAPTPOLBBACE1 | |
| SCHEMBL10502752 | 0.72 | PDE4A (0.40) | ABCB11MAPTBACE1PDE4APDE4B | |
| SCHEMBL9713725 | 0.72 | PDE4A (0.38) | ABCB11MAPTBACE1PDE4APDE4B | |
| SCHEMBL9629311 | 0.72 | HTT (0.55) | MRGPRX4ABCB11CHRM1MAPTPLA2G1B | |
| SCHEMBL1037978 | 0.71 | CHRM1 (0.57) | MRGPRX4CHRM1MAPTPLA2G1BATG4B | |
| SCHEMBL27971141 | 0.70 | MAP2 (0.62) | MAP2MAPTPOLBMEN1KMT2A | |
| SCHEMBL134715 | 0.69 | KMT2A (0.57) | ABCB11MAPTTTRLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0146145-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |
| US-4593120-A | Naphthalene-1,4-dicarboxylic acid group | SYNTEX (U.S.A.) INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0146145-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-06-26 | — | — | EP | disclosed |